Desktop security as a three-dimensional problem

In this paper we argue against viewing computer desktop security solely as a technical issue. Instead, we propose a perspective that combines three related dimensions: technical infrastructure, usability and user engagement. In this light, we suggest that a viable approach to desktop security should embrace these three key dimensions of the end-user context. An example desktop application is described that has been engineered to embody these dimensions in support of the desktop user

Online learning : towards enabling choice

Education is rapidly evolving from an opportunity that was provided mainly for an elite to one that is available to a mass markets and as such is prone to the forces generated by this environment. Where, in the established pattern, commercial interest was limited mainly to the use of skills developed during the educational process, the future model of educational provision will involve extensive commercial activity in the production, delivery and marketing of material. Already there are a number of commercial companies offering framework products enabling "off the shelf solutions" for the construction and delivery of web based courses in any subject area. The commercialisation of education is underway and it is inevitable that it will be viewed, by entrepreneurs and customers alike, as any other commercial product. It would seem reasonable that the consumer should be able to evaluate the performance of these new modes of working in a similar manner to other commercial products. This paper draws together current thinking on the problems associated with evaluating computer and communication based learning

Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells

Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), the most common cutaneous tumour affecting horses. MicroRNAs (miRNAs), small non-coding RNAs that regulate essential biological and cellular processes, have been found dysregulated in a wide range of tumours. The aim of this study was to identify miRNAs associated with ES. Differential expression of miRNAs was assessed in control equine fibroblasts (EqPalFs) and EqPalFs transformed with the BPV-1 genome (S6-2 cells). Using a commercially available miRNA microarray, 492 mature miRNAs were interrogated. In total, 206 mature miRNAs were differentially expressed in EqPalFs compared with S6-2 cells. Aberrant expression of these miRNAs in S6-2 cells can be attributed to the presence of BPV-1 genomes. Furthermore, we confirm the presence of 124 miRNAs previously computationally predicted in the horse. Our data supports the involvement of miRNAs in the pathogenesis of ES

Drought effects on wheat cultivars using trickle irrigation

Trial 74M32 - The trial was aimed at - 1. Looking for cultivar differences in drought tolerance: particularly involving Gamenya and Insignia. 2. Considering trickle irrigation as a means of controlled water application. Four cultivars were sown at the end of July in salmon gum soil at Merredin. Drought effects on four wheat cultivars in controlled environment Trial 74GL8 - This work was aimed at assessing the performance of the cultivars Gamenya, Gambee, Darkan and Insignia under controlled moisture stress

1975 Drought responses of wheat cultivars - environment responses of subterranean clover.

Environment responses of subterranean clover. Aim - To clarify the responses of four cultivars to temperature, vernalisation and photoperiod. Method - Dinninup, Midland B, Geraldton and Blackwood sub clover was grown in phytotron cabinets under 14 hour and 10 hour photoperiods and temperatures 10°c day/5°c night, l5/l0°c, 20/l5°C, 25/20°c. A seed vernalisation treatment of 6 weeks refrigeration of swelled seed was included. Dissections were made to observe first floral initiation and first flower production was noted. Conclusions - Higher temperatures either had no effect or delayed floral initiation, but accelerated flower development greatly from initiation to anthesis. Photoperiod and vernalisation responses were in floral initiation with little evidence of subsequent effects

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial

<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke. The xanthine oxidase inhibitor allopurinol lowers uric acid but also attenuates expression of inflammatory adhesion molecules in murine models, reduces oxidative stress in the vasculature, and improves endothelial function. We sought to investigate whether allopurinol alters expression of inflammatory markers after acute ischemic stroke.</p> <p><b>Methods</b>: We performed a randomized, double-blind, placebo-controlled trial to investigate the safety, tolerability, and effect of 6 weeks’ treatment with high- (300 mg once a day) or low- (100 mg once a day) dose allopurinol on levels of uric acid and circulating inflammatory markers after ischemic stroke.</p> <p><b>Results</b>: We enrolled 50 patients with acute ischemic stroke (17, 17, and 16 in the high, low, and placebo groups, respectively). Mean (±SD) age was 70 (±13) years. Groups had similar characteristics at baseline. There were no serious adverse events. Uric acid levels were significantly reduced at both 7 days and 6 weeks in the high-dose group (by 0.14 mmol/L at 6 weeks, P=0.002). Intercellular adhesion molecule-1 concentration (ng/mL) rose by 51.2 in the placebo group, rose slightly (by 10.6) in the low-dose allopurinol group, but fell in the high-dose group (by 2.6; difference between groups P=0.012, Kruskal-Wallis test).</p> <p><b>Conclusion</b>: Allopurinol treatment is well tolerated and attenuates the rise in intercellular adhesion molecule-1 levels seen after stroke. Uric acid levels were lowered with high doses. These findings support further evaluation of allopurinol as a preventive measure after stroke.</p&gt

A case of pleural mesothelioma with effusive-constrictive pericarditis.

A case report is presented of pleural mesothelioma with simultaneous development of benign effusive-constrictive pericarditis

Growth regulator trials. Part 1

This summary covers 1981 trials on chlormequat plant growth regulant (formulated as Cycocel 750A or Halloween), ECO organic seed dressing and a range of organic foliar sprays. Rates and times of application of chlormequat on wheat. 81A22, 81BA3, 81Cl8, 81E25, 81M22, 81MT2, 81N4, 81SG36, 81WH4. Effects of chlormequat on wheat varieties (S4 trials). 81A6, 81BA7, 81C6, 81E6, 81M9, 81M13, 81MT9, 81N10, 81SG26, 81WH19. Trials comparing organic seed treatments, organic foliar sprays and plant growth regulators. 81WH61, 81LG34, 81LG48, 81ME27a, 81ME276, 81TS39, 81ES51, 81ES52, 81ES53, 81ES54, 81NA57, 81N4A, 81MT2A, 81TS38A. H. McCashney, Cadoux Un-numbered, Newdegate Research Station